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The natural history of obesity is measured in years, whereas the studies cited are restricted to few weeks thus, the total impact of drug-induced weight loss over that of diet alone must be considered clinically limited. Whether these isolated cases can be extrapolated phendimetrazine acquistare spediti merluzzo into general principle is questionable, but such reports raise questions worthy of further scientific investigation. The most severe manifestation of chronic intoxications is psychosis, often clinically indistinguishable from schizophrenia.