SOMATOSTATIN
by Sebastien DESNOS and Ambroise GARRY
PHYSIOLOGY/RECEPTORS OF SOMATOSTATIN
SOMATOSTATIN is a little peptide of 14 or 28 amino-acids which is implicated in many physiology mechanisms. This targets cells localized in the hypothalamus, liver, and gastrointestinal tractus (pancreas, stomach...). Somatostatin has 5 receptors which can create a link. This receptors are STTR (somatostatin transmembrane receptors).
A brief summary about somatostatin
Some characteristics about this molecule and its receptors
SS is injected when patients have cancer (sometimes). Here the subtype 2 is important to stop metastase to inhibit growth hormone secretion
This picture shows the mechanism of proliferation/differenciation implicated somatostatin (inhibit GH also cellular proliferation) and GH or EGF (activated proliferation). Subtypes can regulate proliferation and that's why SS is injected when there's metastase.
This picture shows an example of the mechanism implicated somatostatin (activation of receptors -activation oc AC...).
A new protocol which is based again on the STTR of subtype 2
Different analogues of SS can be used in medecine for the treatment of cancer. These analogues have a greater half-life than SS.
This site speaks about the SS's analogues:
Another mechanism about SS on insulin secretion.