There are, however, no adequate and well-controlled studies in pregnant women. In terms of overall ondansetron turnover, CYP3A4 played the predominant role. In vitro metabolism studies have shown that ondansetron is substrate for human hepatic cytochrome ostaa postimyynti zofran P-450 enzymes, including CYP1A2, CYP2D6, and CYP3A4. If you notice other effects not listed above, contact your doctor or pharmacist. The crucial difference: putting big decisions in the hands of our scientists. Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes CYP3A4, CYP2D6, CYP1A2 inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your health care professional.