Active liver diseases or unexplained transaminase elevations are contraindications to the use of simvastatin. Simvastatin is specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate limiting step in the biosynthetic pathway for cholesterol. buy simvastatin without doctor Simvastatin side effects Get emergency medical help if you have any of these signs of an allergic reaction: difficulty swelling of your face, lips, tongue, or throat. Many of the patients who have developed rhabdomyolysis on therapy with simvastatin have had complicated medical histories, including renal insufficiency usually as consequence of long-standing diabetes mellitus. As listed below elevated plasma levels of HMG-CoA reductase inhibitory activity can increase the risk of myopathy and rhabdomyolysis, particularly with higher doses of simvastatin. If someone else has these foot probblem without haveing other problems, please replay or email me at khaney46 yahoo.