Therefore, before using this product, tell your doctor or pharmacist of all the products you use. The absolute risk of probable dementia for CE MPA versus placebo was 45 versus 22 cases per 10,000 women-years, and the absolute excess risk for CE MPA was 23 cases per 10,000 women-years. prometrium 100 mg & estrace 1mg per day Assume comfortable position, either standing with one leg up, squatting, or lying down. Other side effects may include vaginal discomfort, abdominal pain, or genital itching. These observations are preliminary, and the study is continuing. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Contact your healthcare provider if you have difficulty removing the vaginal ring.