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Precautions General Impaired Hepatic Function may diminish metabolism of Labetalol. This drug may rarely cause serious rarely fatal liver disease. Warnings Hepatic Injury Severe hepatocellular injury, confirmed by rechallenge in at least one case, occurs rarely with therapy with labetalol. The oral LD50 value of labetalol HCl in the mouse is approximately 600 mg kg and in the rat is greater than kg. Therefore, diabetics taking medications that lower blood sugar such as kjope labetalol online ingen resept insulin or oral anti-diabetic medications may need to increase the frequency with which they monitor their blood sugar in order to prevent hypoglycemia. Because the antihypertensive actions of labetalol are not accompanied by an increase in cardiac output, the drug is particularly useful in the management of aortic dissection.